Diabetes is a common life-long condition and the number of children being diagnosed with type 1 diabetes is increasing. The symptoms can be controlled but there is no cure. For many, diabetes means living with daily insulin injections and the possibility of long-term damage to their health. How might stem cells help?
How is diabetes treated at the moment?
Currently there is no cure for diabetes. Although type 2 diabetes can often be at least partially controlled by a healthy diet and regular exercise, type 1 diabetes cannot. People with type 1 diabetes must test their blood sugar levels several times a day and inject insulin when it is needed. Unfortunately it can still be hard to keep the sugar level normal, even with regular injections. Over time, high blood sugar levels can cause serious damage to the heart, eyes, blood vessels, kidneys and nerves, whilst injecting too much insulin can lead to a blood sugar level that’s too low (hypoglycaemia) and this can be fatal.
How could stem cells help?
Instead of islet transplantation with high risks and difficult to find the donor, new beta cells could be grown from stem cells and used in replacement therapy.
About the Stem Cell Therapy:
MNCs and MSCs implantation are used in the treatment for diabetes, combined with conventional therapies:
About stem cells:
MNCs: “MNCs” is an abbreviation for mononuclear cells, better known as "monocytes." These cells are isolated from the patient’s own peripheral circulation. The term “MNCs” actually refers to a selected population comprised of several kinds of stem cells.
MSCs: MSCs (Mesenchymal Stem Cells) are collected from the umbilical cord blood. Because MSCs are primitive cells, they have very low immunogenicity. Therefore, it is unnecessary to have matching tests before transplantation and patient doesn't need to take any immunosuppressive medicine after the treatment.
About the stem cells delivery:
There are two ways to deliver stem cells into the body:
a) Interventional therapy: in this method, stem cells are infused directly into the pancreas through a femoral artery catheter. Once infused into the pancreas, the stem cells can proceed to repair the injured islet β cells and promote the recovery of the pancreatic function.
b) IV injections: the stem cells circulate around the whole body to repair the injured blood vessels and improve whole body, including the pancreas, via the systemic circulation.
Measures of Therapeutic Success:
1. Becoming free of the need for insulin and/or other diabetic medication;
2. Becoming less dependent upon insulin and/or other diabetic medication;
3. Less risk of hypoglycemia;
4. Recovery of islet β cell function (more natural insulin/less need for injection or medication;
5. FPG, 2HPG and HbA1C trend toward normal;
6. Diminished frequency of of diabetic symptoms,
7. Clinically cure/improvement of diabetic complications (neuralgia, ulcer, nephropathy, etc.)
The Advanced Medical Equipment for Interventional therapy of Diabetes
This is the Premier in China of the GE Discovery IGS 730 “Intelligent Robot” high-end compound operating room.
Advantages of the “Compound Operating Room:
1. Patients enter operating room more quickly, especially important for patients in emergencies;
2. Shortened treatment time, making the operation safer;
3. Limits transfer times between therapeutic interventions, thus avoiding risks in the process of transport such as oxygen deficits and cardiovascular compromise;
4. Focused and expedited professional care;
5. Immediate evaluation of the procedures, and reduced complications.
Department Head(s) : Diabetes /Endocrinology
Dr. Maode Yang
Dr. Yang graduated from Peking University Health Science Center (formerly Beijing Medical College), where he received his PhD and did a post-doctoral fellowship in immunology at Wellcome Research Laboratories (UK) as well as at the DNAX Research Institute (USA). Over the past decade, Dr Yang’s work has successfully focused on Immune therapy for diabetes: the results have been significant. Dr. Yang has successfully treated many patients with Type-II diabetes, after which patients have been able to reduce their medicine/insulin dosages by as much as 50%, including some who have been able to discontinue using insulin and/or oral medicine. Dr Yang plans to continue to refine this immune therapy for diabetes, and improve the condition of many more patients with Type II diabetes.
Area of Specialization: Cellular Immune Therapy (CIT) for diabetes and its complications.
Dr. Chi Lian
Dr. Chi graduated from Heilongjiang Jiamusi Medical School, and has devoted herself to the treatment of diabetes since 1999. With more than 10 years of clinical experience, Dr. Chi has achieved great acumen in both the diagnosis and the treatment of diabetes. As one of China's leading experts in applied biological treatment for diabetes, Dr. Chi has achieved many positive outcomes, and is becoming a world leader of this exciting clinical frontier. Dr Chi expresses every confidence that applied medical bioscience will eventually defeat diabetes and other diseases, as understanding and clinical applications are refined.
Beginning in China, innovative biological treatment for diabetes, such as the biological program at Puhua International Hospitals-Temple of Heaven, are lighting the future of clinical medicine.
Department Head(s) : General MedicineMore category items
Diabetes CASE STUDIES
Name: Mr. Liu
Diagnosis: Type II Diabetes
D.O.B: 01 January 1966
Name: John Clarke
Diagnosis: Dilated Cardiomyopathy (DCM); Atherosclerosis; Cardiac Failure-Functional Class Ⅲ; Pacemaker Implantation After Surgery; Hx of Transient Ischemic Attack; COPD; Severe Obesity; Type 2 Diabetes; Mixed Sleep Apnea Syndrome; Peripheral Vascular Disease; Intercostal Neuralgia
D.O.B: 12 February 1962